abstract：:Hypermethylation of the MGMT gene promoter and mutation of the TP53 tumor-suppressor gene are frequently present in diffuse astrocytomas. However, there is only anecdotal information about MGMT methylation status and TP53 mutations during progression of low-grade diffuse astrocytoma (AII) to anaplastic astrocytoma (AI...

journal_title：Journal of neuro-oncology

authors： Groenendijk FH,Taal W,Dubbink HJ,Haarloo CR,Kouwenhoven MC,van den Bent MJ,Kros JM,Dinjens WN

更新日期：2011-02-01 00:00:00

abstract：:Optimal treatment of anaplastic oligodendroglial tumors (AOT) in elderly patients is debatable. We report a retrospective study of 44 consecutive patients aged 70 years or older [median age: 74 years; median Karnofsky performance status (KPS): 70] treated with up-front chemotherapy using temozolomide (TMZ) at conventi...

journal_title：Journal of neuro-oncology

authors： Ducray F,del Rio MS,Carpentier C,Psimaras D,Idbaih A,Dehais C,Kaloshi G,Mokhtari K,Taillibert S,Laigle-Donadey F,Omuro A,Sanson M,Delattre JY,Hoang-Xuan K

更新日期：2011-02-01 00:00:00

abstract：:Differentiating neoplastic from non-neoplastic intracranial lesions is of paramount importance for patient management. Benign lesions can have many of the features of malignant brain tumors on both computed tomography (CT) and conventional magnetic resonance imaging (MRI). Herewith, we set out to investigate the role ...

journal_title：Journal of neuro-oncology

authors： Fotopoulos AD,Kyritsis AP,Tsiouris S,Al-Boucharali J,Papadopoulos A,Voulgaris S,Alexiou GA

更新日期：2011-01-01 00:00:00

abstract：:Various subtypes of intracerebral hamartomas, associated with seizure disorders, have long been described. We describe a cerebral hamartoma placed in the left frontal lobe, associated with drug-resistant epilepsy, composed exclusively of mature oligodendroglial cells. The patient was a 27-year-old right-handed male pr...

journal_title：Journal of neuro-oncology

authors： Marucci G,Giulioni M,Martinoni M,Volpi L,Michelucci R

更新日期：2011-01-01 00:00:00

abstract：:The main problem in the treatment of malignant astrocytomas is their invasive behaviour. Successful resection of the main tumour mass cannot prevent recurrence due to single cells invading the surrounding brain parenchyma at the time of diagnosis. The classical combination therapy, PCV (Procarbazine, CCNU and Vincrist...

journal_title：Journal of neuro-oncology

authors： Kinsella P,Clynes M,Amberger-Murphy V

更新日期：2011-01-01 00:00:00

abstract：:Glioblastoma (GBM) is the most common and deadly form of primary brain tumor with a median survival of eleven months, despite use of extensive chemotherapy, radiotherapy and surgery. We have previously shown that nuclear factor-kappa B (NF-κB) is aberrantly expressed in GBM tumors and primary cell lines derived from t...

journal_title：Journal of neuro-oncology

authors： Raychaudhuri B,Vogelbaum MA

更新日期：2011-01-01 00:00:00

abstract：:We previously showed that inhibition of the platelet-derived growth factor receptor (PDGFR) blocks the survival and migration of medulloblastoma cells. Identification of in vitro PDGFR-targeting pharmacologic agents that are suitable for preclinical testing in medulloblastoma models in vivo will be critical for effici...

journal_title：Journal of neuro-oncology

authors： Abouantoun TJ,Castellino RC,MacDonald TJ

更新日期：2011-01-01 00:00:00

abstract：:Malignant primary spinal cord gliomas (PSCGs) are rare, and the optimal treatment for these lesions remains controversial. We report herein treatment outcomes of six malignant PSCGs managed with temozolomide (TMZ)-based multidisciplinary treatment. TMZ was administered concomitantly with fractionated radiotherapy for ...

journal_title：Journal of neuro-oncology

authors： Kim WH,Yoon SH,Kim CY,Kim KJ,Lee MM,Choe G,Kim IA,Kim JH,Kim YJ,Kim HJ

更新日期：2011-01-01 00:00:00

abstract：:Extraskeletal myxoid chondrosarcoma is a rare tumor with less than 100 cases reported in the literature. The prevalence of anti-Hu positive myxoid chondrosarcoma-associated paraneoplastic subacute cerebellar degeneration is exceedingly rare. We present a report of a patient with confirmed myxoid chondrosarcoma-associa...

journal_title：Journal of neuro-oncology

authors： Hoosien M,Vredenburgh J,Lanfranco J,Ochoa R,Robinson P,Martinez R,Singer C,Silva O

更新日期：2011-01-01 00:00:00

abstract：:NeuroCogFX is a short yet comprehensive computer-based neuropsychological battery of tests developed to investigate neurological patients for cognitive dysfunction after potentially neurotoxic therapy. NeuroCogFX had been standardized in a group of 242 healthy controls (Fliessbach et al., Fortschr Neurol Psychiatr 74:...

journal_title：Journal of neuro-oncology

authors： Fliessbach K,Rogowski S,Hoppe C,Sabel M,Goeppert M,Helmstaedter C,Calabrese P,Schackert G,Tonn JC,Simon M,Schlegel U

更新日期：2010-12-01 00:00:00

abstract：:We report one year follow up of a case of extramedullary hematopoiesis within the clivus. The imaging findings, brief clinical course, and endoscopic transphenoidal approach are described. A 29-year-old female with thalassemia developed worsening cranial nerve signs. After imaging studies discovered a large clival mas...

journal_title：Journal of neuro-oncology

authors： Reames DL,Lindstrom K,Raghavan P,Jane J Jr

更新日期：2010-12-01 00:00:00

abstract：:Bevacizumab is effective for the treatment of non-small cell lung cancer (NSCLC). Ongoing trials are exploring the safety of bevacizumab in patients with inactive, previously treated brain metastases. However, bevacizumab safety and efficacy in the treatment of active brain metastases is unknown. Bevacizumab received ...

journal_title：Journal of neuro-oncology

authors： De Braganca KC,Janjigian YY,Azzoli CG,Kris MG,Pietanza MC,Nolan CP,Omuro AM,Holodny AI,Lassman AB

更新日期：2010-12-01 00:00:00

abstract：:Since its description in 1982, central neurocytoma (CN) has been a relatively innocuous rare tumor of the central nervous system. Comprising of less than 0.5% of all intracranial tumors, most are reported to be slow growing, with low recurrence rates, and a favorable prognosis. Because of its rarity, its cellular biol...

journal_title：Journal of neuro-oncology

authors： Tran H,Medina-Flores R,Cerilli LA,Phelps J,Lee FC,Wong G,Turner P

更新日期：2010-11-01 00:00:00

abstract：:Glioblastoma multiforme is the most frequent and aggressive primary brain tumor. A strong rationale to identify innovative approaches to treat these tumors is required since treatment failures result in local recurrences and median survivals range from 9 to 12 months. Glioma cells are reported to have less mitochondri...

journal_title：Journal of neuro-oncology

authors： Huang Z,Jiang J,Belikova NA,Stoyanovsky DA,Kagan VE,Mintz AH

更新日期：2010-10-01 00:00:00

abstract：:Anaplastic oligodendroglioma (AO) is an uncommon intracranial tumor and prognosis is poor. In this study, we assessed the factors affecting the prognosis of AO patients. Seventy AO patients were recruited from 2001 to 2006 in Shanghai Huashan Hospital of Fudan University; all were treated surgically. Kaplan-Meier surv...

journal_title：Journal of neuro-oncology

authors： Yang LS,Huang FP,Zheng K,Zhang HS,Zhou X,Bao XH,Zheng JJ,Chang C,Zhou LF

更新日期：2010-10-01 00:00:00

abstract：:Brain tumor patients undergo various combinations therapies, leading to very complex and confusing imaging appearances on follow up MR imaging and hence, differentiating recurrent or progressing tumors from treatment induced necrosis or effects has always been a challenge in neuro-oncologic imaging. This particular to...

journal_title：Journal of neuro-oncology

authors： Jain R,Narang J,Sundgren PM,Hearshen D,Saksena S,Rock JP,Gutierrez J,Mikkelsen T

更新日期：2010-10-01 00:00:00

abstract：:Pituitary adenomas produce the chemokine stromal cell-derived factor (SDF-1α/CXCL12) and its receptor, CXCR4. A recent study indicated that CXCL12 and CXCR4 are concomitantly up-regulated in hypoxia. The objective of this study was to analyze the molecular mechanism of hypoxia-mediated CXCR4 up-regulation and assess t...

journal_title：Journal of neuro-oncology

authors： Yoshida D,Koketshu K,Nomura R,Teramoto A

更新日期：2010-10-01 00:00:00

abstract：:Meningiomas, when benign, are commonly treated with surgical resection alone. However, the optimal treatment for patients with subtotally resected or recurrent World Health Organization (WHO) grade I tumors, or WHO grade II and III tumors, regardless of the extent of resection, is not well defined, with both a paucity...

journal_title：Journal of neuro-oncology

authors： Vogelbaum MA,Leland Rogers C,Linskey MA,Mehta MP

更新日期：2010-09-01 00:00:00

abstract：:Aberrant activation of Akt is a common finding in adult malignant gliomas, resulting in most cases from mutations or deletions involving PTEN, which allows constitutive Akt phosphorylation. In contrast, we have previously reported that pediatric malignant gliomas, which are morphologically similar to lesions arising i...

journal_title：Journal of neuro-oncology

authors： Pollack IF,Hamilton RL,Burger PC,Brat DJ,Rosenblum MK,Murdoch GH,Nikiforova MN,Holmes EJ,Zhou T,Cohen KJ,Jakacki RI,Children's Oncology Group.

更新日期：2010-09-01 00:00:00

abstract：:Steady improvements in imaging modalities have enabled a new realm of capabilities in the identification and assessment of meningiomas. The cross-sectional imaging modalities, MRI and CT, have improved in resolution and fidelity. These modalites now provide not only improved structural information but also insights in...

journal_title：Journal of neuro-oncology

authors： Saloner D,Uzelac A,Hetts S,Martin A,Dillon W

更新日期：2010-09-01 00:00:00

abstract：:To characterize a population of pediatric high-grade astrocytoma (HGA) patients by confirming the proportion with a correct diagnosis, and determine prognostic factors for survival in a subset diagnosed with uniform pathologic criteria. Sixty-three children diagnosed with HGA were treated at the Johns Hopkins Hospital...

journal_title：Journal of neuro-oncology

authors： Hales RK,Shokek O,Burger PC,Paynter NP,Chaichana KL,Quiñones-Hinojosa A,Jallo GI,Cohen KJ,Song DY,Carson BS,Wharam MD

更新日期：2010-08-01 00:00:00

abstract：:Meningiomas in identical twins are extremely rare. To our knowledge, only one previous report of meningiomas in identical twins has been published. We present identical twin sisters with meningiomas. The tumors were located at a similar, but not a common, position (the cerebellopontine angle) in both twins. Histologic...

journal_title：Journal of neuro-oncology

authors： Ohba S,Yoshida K,Hirose Y,Ikeda E,Kawase T

更新日期：2010-07-01 00:00:00

abstract：:The aim of this work is to evaluate patterns of failure in patients with recurrent meningioma after stereotactic radiotherapy. Of 411 patients with intracranial meningioma treated with radiotherapy at our institution, 22 patients with local tumor progression diagnosed by magnetic resonance imaging (MRI) after radiothe...

journal_title：Journal of neuro-oncology

authors： Askoxylakis V,Zabel-du Bois A,Schlegel W,Debus J,Huber P,Milker-Zabel S

更新日期：2010-07-01 00:00:00

abstract：:We have retrospectively reviewed toxicities and response of a cohort of primary central nervous system lymphoma (PCNSL) patients treated with high dose parenteral methotrexate (MTX) monotherapy without whole brain radiation. From The Massachusetts General Hospital (MGH) Cancer Registry, active since 1946, we selected ...

journal_title：Journal of neuro-oncology

authors： Cobert J,Hochberg E,Woldenberg N,Hochberg F

更新日期：2010-07-01 00:00:00

abstract：:The aim of this work was to determine the accuracy and precision of stereotactic localization and treatment delivery using a helical tomotherapy based stereotactic radiosurgery (SRS) system. A tomotherapy specific radiosurgery workflow was designed that exploits the system's on board megavotage CT (MVCT) imaging syste...

journal_title：Journal of neuro-oncology

authors： Soisson ET,Hardcastle N,Tomé WA

更新日期：2010-06-01 00:00:00

abstract：:Patients with metastatic well-differentiated thyroid cancer have a generally favorable long-term outcome although multi-organ involvement is a known marker of poor prognosis. Brain metastases are rare, occurring in less than 1% of patients with thyroid cancer. Few patients have been managed with stereotactic radiosurg...

journal_title：Journal of neuro-oncology

authors： Bernad DM,Sperduto PW,Souhami L,Jensen AW,Roberge D

更新日期：2010-06-01 00:00:00

abstract：:We evaluated the results of stereotactic radiosurgery (SRS) alone using gamma knife (GK) for selected patients with 1-10 brain metastases without prophylactic whole-brain radiation therapy (WBRT) among JLGK0901-eligible cases. Seven hundred seventy-eight consecutive cases meeting the following JLGK0901 study inclusion...

journal_title：Journal of neuro-oncology

authors： Serizawa T,Hirai T,Nagano O,Higuchi Y,Matsuda S,Ono J,Saeki N

更新日期：2010-06-01 00:00:00

abstract：:Ependymomas are glial neoplasms originating from the wall of the ventricles or from the spinal canal. The significance of histopathological features in accurately predicting biological behavior is still debated. Moreover, key molecular events in the pathogenesis of ependymoma are yet to be defined. The main objective ...

journal_title：Journal of neuro-oncology

authors： Rousseau A,Idbaih A,Ducray F,Crinière E,Fèvre-Montange M,Jouvet A,Delattre JY

更新日期：2010-05-01 00:00:00

abstract：:Leptomeningeal dissemination of low-grade gliomas is an uncommon event. A 43-year old male presented with dizziness, gait ataxia, and diplopia. A nonenhancing lesion in the right cerebellar peduncle was identified, subtotally resected, and diagnosed as a grade II astrocytoma. After one year a nodular spread in the bra...

journal_title：Journal of neuro-oncology

authors： Passarin MG,Moretto G,Musso AM,Ottaviani S,Masotto B,Ghimenton C,Iuzzolino P,Buffone E,Rudà R,Soffietti R,Vattemi E,Pedersini R

更新日期：2010-05-01 00:00:00

abstract：:Extra-axial cerebellopontine angle (CPA) tumors account for approximately 10% of all brain neoplasms in adults. Vestibular schwannomas are the most common, followed by meningiomas. Gliomas in the CPA are rare and quite often are the exophytic extension of primary brain stem or cerebellar tumors. We describe a pilocyti...

journal_title：Journal of neuro-oncology

authors： Francesco F,Maurizio I,Stefano C,Marina S,Ugo S,Massimo S

更新日期：2010-04-01 00:00:00

abstract：:CCAAT/enhancer binding protein (C/EBP) delta is a transcription factor which has been demonstrated to mediate the growth arrest of mammary and prostate cancer cell lines. It is induced by several stimuli including inflammatory cytokines. In this study, C/EBPdelta immunohistochemical expression was assessed in 49 menin...

journal_title：Journal of neuro-oncology

authors： Barresi V,Vitarelli E,Cerasoli S,Barresi G

更新日期：2010-04-01 00:00:00

abstract：:Paraneoplastic cerebellar degeneration is a rare neurological disorder that frequently precedes the detection of malignancy. Here, we report the case of a 60 year-old woman with locally advanced squamous cell carcinoma of the tongue who developed a subacute cerebellar syndrome associated with the presence of anti-CV2/...

journal_title：Journal of neuro-oncology

authors： Saloustros E,Zaganas I,Mavridis M,Vamvakas L,Plaitakis A,Georgoulias V,Mavroudis D

更新日期：2010-04-01 00:00:00

abstract：:Although their neurocognitive performance is one of the major concerns of patients with high-grade gliomas (HGG) and although neurocognitive deficits have been described to be associated with negative outcome, neurocognitive rehabilitation is usually not integrated into the routine care of patients with malignant glio...

journal_title：Journal of neuro-oncology

authors： Hassler MR,Elandt K,Preusser M,Lehrner J,Binder P,Dieckmann K,Rottenfusser A,Marosi C

更新日期：2010-03-01 00:00:00

abstract：:Intracranial metastatic prostate carcinoma is rare. We sought to determine the clinical outcomes after Gamma Knife stereotactic radiosurgery (GKSRS) for patients with intracranial prostate carcinoma metastases. We studied data from 10 patients who underwent radiosurgery for 15 intracranial metastases (9 dural-based an...

journal_title：Journal of neuro-oncology

authors： Flannery T,Kano H,Niranjan A,Monaco EA 3rd,Flickinger JC,Lunsford LD,Kondziolka D

更新日期：2010-02-01 00:00:00

abstract：QUESTION:Should patients with newly-diagnosed metastatic brain tumors undergo open surgical resection versus whole brain radiation therapy (WBRT) and/or other treatment modalities such as radiosurgery, and in what clinical settings? Target population These recommendations apply to adults with a newly diagnosed single b...

journal_title：Journal of neuro-oncology

authors： Kalkanis SN,Kondziolka D,Gaspar LE,Burri SH,Asher AL,Cobbs CS,Ammirati M,Robinson PD,Andrews DW,Loeffler JS,McDermott M,Mehta MP,Mikkelsen T,Olson JJ,Paleologos NA,Patchell RA,Ryken TC,Linskey ME

更新日期：2010-01-01 00:00:00

abstract：:Chordomas constitute about 1% of intracranial tumors. They are generally extradural destroying the bone. Intradural chordomas are very rare. We present one such case of a clival intradural chordoma who presented with a left trigeminal nerve sensory neuropathy. The lesion was totally excised uneventfully via a retromas...

journal_title：Journal of neuro-oncology

authors： Bhat DI,Yasha M,Rojin A,Sampath S,Shankar SK

更新日期：2010-01-01 00:00:00

abstract：:A retrospective evaluation of single agent bevacizumab in adults with recurrent glioblastoma (GBM) with an objective of determining progression free survival (PFS). There is no standard therapy for recurrent GBM after failure of alkylator-based chemotherapy. A total of 50 adults, ages 36-70 years (median 64), with rec...

journal_title：Journal of neuro-oncology

authors： Chamberlain MC,Johnston SK

更新日期：2010-01-01 00:00:00

abstract：:According to World Health Organization (WHO) and Daumas-Duport grading systems, progression of oligodendrogliomas (ODGs) to a higher grade (WHO grade III, grade B) is associated with increased angiogenesis. Based on multivariate assessment of molecular, pathological, and radiological parameters, we further assessed th...

journal_title：Journal of neuro-oncology

authors： Quon H,Hasbini A,Cougnard J,Djafari L,Lacroix C,Abdulkarim B

更新日期：2010-01-01 00:00:00

abstract：:The aim of this article is to evaluate and assess the impact of various factors on quality of life (QOL) in adult patients with primary brain tumors seen consecutively in routine neurooncology practice. Two hundred and fifty-seven adult patients, after undergoing surgical intervention and histologically proven primary...

journal_title：Journal of neuro-oncology

authors： Budrukkar A,Jalali R,Dutta D,Sarin R,Devlekar R,Parab S,Kakde A

更新日期：2009-12-01 00:00:00

abstract：:Chordoid is a rare variant of meningioma that displays a high recurrence rate. In this study we evaluated the immunohistochemical expression of factors that regulate the neo-angiogenesis process in a case of chordoid meningioma with an adverse clinical course. A high microvessel density (MVD), as well as high VEGF and...

journal_title：Journal of neuro-oncology

authors： Barresi V,Tuccari G

更新日期：2009-12-01 00:00:00